Prior to, much of my client-side scripting experience was done on line of business applications with small to large doses of jQuery, jQuery plug-ins, jQuery AJAX, jQuery this, jQuery that, etc., etc., etc.
Let's rewind a bit...
NOT A GOOD ANSWER: Yes, I've done a lot with jQuery.
Or as I like to call it, jQuery Goggles.
Fast forward to my HTML5 game...
I'm simply saying that if you're wearing the jQuery Goggles, not only is it a good time to take them off, there's a world beneath, far more elegant than you may think.